Istamet D-XR 1000 Tablet

Istamet D Xr Tablet is a combination medication used to manage blood sugar levels in adults with type 2 diabetes mellitus. It contains a combination of dapagliflozin, metformin, and sitagliptin as its active ingredients. This medicine should be used alongside a healthy diet and exercise routine to enhance blood sugar control.

Istamet D Xr Tablet helps the body utilise insulin effectively, thereby lowering blood sugar levels. Istamet D Xr Tablet can be taken with or without food at any time of the day, but it's best to take it consistently at the same time each day. Your doctor will determine the appropriate dosage, and it's important not to discontinue the medication without their guidance.

Abruptly stopping the medication may result in increased blood sugar levels, raising the risk of serious complications such as kidney damage and blindness. Common side effects of Istamet D Xr Tablet include urinary tract infections, nasal congestion, sore throat, and upper respiratory tract infections. To prevent dehydration, drinking plenty of fluids while using this medication is essential.

Some individuals might experience fungal infections in the genital area, which can be managed by maintaining good hygiene. Before starting this medication, inform your doctor if you have any kidney or liver issues, a urinary tract infection, or if you are taking diuretics. Pregnant or breastfeeding women should seek medical advice before using it.

Avoid excessive alcohol consumption as it can increase the likelihood of side effects. Regular monitoring of blood sugar levels is crucial while taking this medication.

Dosage

Overdose

If you think you have taken too much of Istamet D Xr Tablet, contact your doctor immediately or visit the nearest hospital.

Missed a Dose

• If you missed a dose of Istamet D Xr Tablet, take it as soon as you remember.
• If it's time for your next dose, then skip the missed dose and continue with your regular dosing schedule.
• Do not take a double dose to compensate for the missed dose.

Mode of Action

How Does It Work?

• Istamet D Xr Tablet contains a combination of sitagliptin, metformin, and dapagliflozin as active substances. Dapagliflozin reduces blood glucose levels by increasing urinary glucose excretion. Metformin reduces glucose absorption from food and glucose production by the liver, while increasing the body's response to insulin. Sitagliptin helps control blood sugar levels by increasing insulin release and signaling the liver to stop producing sugar when blood sugar levels are high.

Directions for Use

• Istamet D Xr Tablet should be taken exactly as directed by your doctor.
• Swallow it as a whole with a glass of water.
• Do not cut, break or chew the medicine.
• Do not take more than the prescribed dose.

Precautions and Warnings

Pregnancy

Can I take Istamet D Xr Tablet during pregnancy?

There is limited information on the effect of Istamet D Xr Tablet in pregnant women. Therefore, this medicine should not be used during pregnancy. Before starting treatment with this medicine, inform your doctor if you are pregnant or planning on becoming pregnant.

Breast Feeding

Can I take Istamet D Xr Tablet while breastfeeding?

No information is available if Istamet D Xr Tablet passes into human breast milk. Thus, this medicine should not be used in breastfeeding women. Before starting treatment with this medicine, inform your doctor if you are breastfeeding or lactating.

Driving

Can I drive if I have used Istamet D Xr Tablet?

Istamet D Xr Tablet has no or negligible effect on driving ability. However, if you experience any effects like dizziness or sleepiness after taking this medicine that may affect your ability to drive safely, it is advised to avoid driving.

Alcohol

Can I consume alcohol with Istamet D Xr Tablet?

Alcohol should not be used together with Istamet D Xr Tablet as it may cause complications like diabetic ketoacidosis.

Other General Warnings

Talk to your doctor if

• You have type 1 diabetes or a complication of diabetes called diabetic ketoacidosis.
• You develop symptoms of acute pancreatitis like continuous and severe abdominal pain after using this medicine.
• You are taking other anti-diabetic medicines like sulphonylureas or insulin. If you are not sure what these medicines are, please confirm with your doctor.
• You develop allergic reactions like swelling of the face, tongue and lips after using Istamet D Xr Tablet.
• You experience itchy skin with large blisters after taking this medicine.
• You have kidney disease or are on dialysis.
• You have liver disease or heart failure.
• You are taking medicines for managing high blood pressure.
• You have a history of low blood pressure or are elderly ((≥ 65 years).
• You have any illness of the stomach or intestine.
• If you develop symptoms like nausea, vomiting, abdominal pain, excessive thirst, confusion, sleepiness and tiredness after taking this medicine, talk to your doctor immediately.
• You are scheduled for surgery.
• You are dehydrated or have restricted food intake.
• You take alcohol regularly or frequently.
• You notice pain, tenderness, red or pink blotches on the skin, or swelling in the genital or perineal area, with fever or general discomfort after taking Istamet D Xr Tablet. Talk to your doctor immediately.
• You have an infection of the urinary tract.
• You develop blisters or ulcers on your foot while taking Istamet D Xr Tablet. Talk to your doctor immediately.

Contraindications

If you are allergic to sitagliptin, dapagliflozin or any other ingredient of Istamet D Xr Tablet.

Side effects

• Headache
• Dizziness
• Low blood sugar
• Rashes
• Painful urination

Interactions

Interactions with other medicines

• Inform your doctor about all other medicines, herbals or supplements that you are currently taking or might take to avoid any possible interaction.
• Particular care should be taken if you have kidney disorders and are taking medicines for the treatment of fungal infections (ketoconazole), bacterial infections (clarithromycin) or HIV/AIDS (ritonavir).
• Caution should be exercised if you are taking medicines for the management of heart failure (digoxin).
• The use of Istamet D Xr Tablet with diuretics like furosemide and hydrochlorothiazide (used to manage fluid accumulation) may increase the risk of dehydration and low blood pressure.
• This medicine, when used together with insulin and insulin secretagogues (sulphonylurea), may cause extremely low blood sugar levels.

Storage and disposal

• Store Istamet D Xr Tablet in a cool and dry place below 30°C away from direct sunlight.
• Keep out of reach of children and pets.

Frequently Asked Questions (FAQs)

Can I take my other medicines along with Istamet D Xr Tablet?

Your doctor will recommend if it is suitable for you to take Istamet D Xr Tablet along with your other medicines. You should always inform your doctor about all other medicines, herbals or supplements that you are taking or might take to avoid any possible interaction. Do not take any other medicine on your own during treatment with Istamet D Xr Tablet without informing your doctor.

Can Istamet D Xr Tablet be used in children?

Istamet D Xr Tablet is not recommended for use in children below 18 years of age.

When to take Istamet D Xr Tablet?

Istamet D Xr Tablet should be taken exactly as recommended by your doctor. It can be taken with or without food. However, it is recommended to take this medicine at the same time every day for optimal benefits.