Isryl-M2 Tablet

Isryl M2 tablet is an anti-diabetic medication. It contains a combination of glimepiride and metformin as active ingredients. Isryl M2 tablet is used to manage blood sugar levels in type 2 diabetes when glimepiride or metformin alone is not effective.

Do not use this medicine if you are allergic to it or have type 1 diabetes. Take it in the exact dose and duration as prescribed by your doctor. Do not take more than the prescribed dose.

Do not stop taking this medicine on your own. Along with Isryl M2 tablet, it is beneficial to maintain a healthy lifestyle with exercise and dietary modifications for adequate control of your blood sugar levels.

Dosage

Overdose

• Overdose of Isryl M2 tablet may lead to severely low blood sugar levels and lactic acidosis. This can result in headaches, nausea, vomiting, sleep disturbances, restlessness, confusion and dizziness.
• Contact your doctor immediately or visit the nearest hospital if you think you have taken too much of this medicine.

Missed a Dose

If you have missed taking a dose of Isryl M2 tablet, take it as soon as you remember. If it's time for the next dose, skip the missed dose and continue with the regular dose schedule. Avoid taking a double dose to compensate for the missed one.

Mode of Action

How Does It Work?

• Isryl M2 tablet contains a combination of glimepiride and metformin as active ingredients.
• Glimepiride lowers the blood sugar level by increasing the release of insulin hormone from the pancreas. Insulin helps to move sugar (glucose) from the blood into the cells.
• Metformin decreases the absorption in the intestine and the production of sugar by the liver.
• Both of these components are known to increase the insulin sensitivity of the body, which allows the cells of the body to use blood glucose more effectively, thereby reducing blood sugar.

Directions for Use

• Take this medicine as directed by the doctor.
• Swallow it as a whole with a glass of water.
• Do not cut, break or chew the medicine.
• Preferably take it with meals.
• It would be best if you take it at the same time every day for optimal results.
• Avoid consuming more than the dose prescribed by the doctor.

Precautions and Warnings

Pregnancy

Can I take Isryl M2 tablet during pregnancy?

• The use of Isryl M2 tablet during pregnancy is not recommended. Consult the doctor if you are pregnant or think you may be pregnant or are planning to have a baby before starting this medicine.

Breast Feeding

Can I take Isryl M2 tablet while breastfeeding?

• Avoid Isryl M2 tablet if you are a breastfeeding mother as the components of this medicine may pass into human breast milk. Consult the doctor before using medication during breastfeeding.

Driving

Can I drive if I have consumed Isryl M2 tablet?

• There is limited information on the effect of Isryl M2 tablet on driving ability. In case you experience any symptoms of low blood sugar levels like dizziness, drowsiness, vision disturbances, and sweating, stop driving and have sugar/ juice. Avoid consuming sugar-free during such episodes.

Alcohol

Can I consume alcohol with Isryl M2 tablet?

• It is advisable not to consume alcohol during treatment with Isryl M2 tablet.

Other General Warnings

Talk to your doctor if

• You experience extreme hunger, headache, nausea, vomiting, sleepiness, restlessness, aggression, reduced alertness, confusion, shakiness or dizziness. These could be signs of low blood sugar. If you have any of these, immediately have sugar or sweet juice. Inform your doctor.
• You are experiencing pins-and-needles sensation, numbness, and weakness.
• You are going to have a diagnostic imaging test that involves the injection of iodine.
• You have dehydration due to diarrhea, vomiting, or limited fluid intake.
• You have suffered through trauma.
• You have to undergo surgery in the near future.
• You have kidney or liver problems.
• You have a thyroid disorder.
• You are overweight.

Contraindications

• If you are allergic to metformin, glimepiride or any of the ingredients of Isryl M2 tablet.
• If you are allergic to other sulfonylureas or other sulfonamides. If you are not sure what these medicines are, please confirm with your doctor.
• If you have kidney or liver disorders.
• If you are undergoing dialysis.
• If you have type 1 diabetes.
• If you have diabetic ketoacidosis or diabetic pre-coma or coma.

Side effects

• Nausea
• Diarrhoea
• Abdominal pain
• Headache
• Dizziness

Interactions

Interactions with other medicines

• Some medicines can affect the way Isryl M2 tablet works or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
• Inform the doctor regarding the medicines, supplements or herbals you take or might take to avoid possible interaction.
• You may have symptoms of low blood sugar if you are taking other medicines for diabetes like insulin, pioglitazone, medicines for high blood pressure (ACE inhibitors like captopril), steroids, chloramphenicol, fenfluramine, fenyramidol, medicines to lower blood cholesterol (fibrates), medicines to manage depression (fluoxetine), medicines to treat blood clotting like coumarins, cyclophosphamide, miconazole, probenecid, antibiotics like clarithromycin, doxycycline, ofloxacin, etc.
• You may have symptoms of high blood sugar if you are taking oral contraceptives, acetazolamide, water pill, phenytoin, rifampicin, medicines for constipation and medicines for thyroid disorders.
• Medicines like anti-allergics (ranitidine), clonidine, reserpine and medicines used to treat high blood pressure like atenolol can alter the way this medicine works and may block your body's response to low blood sugar. This can lead to dangerously low levels of blood sugar.
• Medicines like diclofenac, ibuprofen, water pill and enalapril may affect your kidney functions if taken along with this medicine.
• Medicines used to treat thyroid disorders can affect the way this medicine works.

Storage and disposal

• Store Isryl M2 tablet at room temperature in a cool and dry place. Protect it from moisture.
• Keep out of the reach of children and pets.

Frequently Asked Questions (FAQs)

What diet should I follow if I am diabetic?

• A diet should be high in fibre and low in fat with adequate protein, carbohydrates, vitamins and minerals.
• Maintain the regular meal timings and try to have soups and salads.
• Diet should include boiled, steamed or baked food.
• Ensure moderate use of edible oils (groundnut oil, olive oil) and very less use of ghee and butter.
• Drink at least 8-10 glasses of water daily.
• Carry fruit or low-calorie high fibre biscuits while travelling.

What should I avoid being a diabetic patient?

• Do not shop when you are hungry. You could be tempted to buy oily and fried food.
• Avoid overeating.
• Avoid maida, white bread, potato, noodles, corn flakes, poori, biryani, naan, fried rice, etc.
• Stop having daals with ghee, deep-fried pulses.
• Avoid cream soups, carrot juice, deep-fried vegetables and vegetable curries with excess oil.

My blood sugar falls too often, what could be the reason?

• Avoid skipping meals, fasting, too much alcohol intake, taking alcohol on an empty stomach and taking a double dose of the medicine.
• If you are taking any other medicines, you need to inform your doctor.
• Always keep a juice or sugar candy with you, in case you experience symptoms of low blood sugar like headache, irritability, drowsiness, reduced alertness or nausea, immediately have the juice or glucose.
• Do not have artificial sweeteners in this situation.
• If such episodes happen too often, inform your doctor as you may need a decrease in the dose of this medicine.

What is Isryl M2 used for?

Isryl M2 tablet is used for effective management of blood sugar levels in type 2 diabetes patients when glimepiride or metformin alone is not effective.

Can Isryl M2 be used in type 1 diabetes?

No, Isryl M2 tablet is contraindicated for use in type 1 diabetes.

Can I take Isryl M2 if I am taking other medicines?

Yes, Isryl M2 tablet can be taken with other medicines if it is recommended by your doctor. Some medicines can affect the way Isryl M2 tablet works or this medicine itself can reduce the effectiveness of other medicines taken at the same time. Thus, you should always inform the doctor about the medicines, supplements or herbals you take or might take to avoid any possible interaction.

Can I give Isryl M2 to my child?

There is limited information on the effect of Isryl M2 tablet in children. This medicine should only be given to your child if it is recommended by your doctor. Do not give this medicine to your child on your own.

What if I miss a dose of Isryl M2?

If you have missed taking a dose of Isryl M2 tablet, take it as soon as you remember. If it's time for the next dose, skip the missed dose and continue with the regular dose schedule. Avoid taking a double dose to compensate for the missed one.

Can I take Isryl M2 daily?

Yes, Isryl M2 tablet should be taken daily at the same time every day. You should take this medicine exactly as recommended by your doctor. Do not take more than the recommended dose.

What is the normal range for blood sugar levels?

A fasting blood sugar level of 99 mg/dL or lower is considered normal. However, you should always discuss your test results with your doctor for confirmation.

What does Isryl M2 contain?

Isryl M2 tablet contains a combination of glimepiride and metformin as active ingredients.

Can I take Isryl M2 if I am taking insulin?

The use of insulin is generally not recommended if you are taking Isryl M2 tablet. However, you should always discuss this with your doctor before starting the medicine. Do not self-medicate.

Can Isryl M2 be used in the elderly?

Yes, Isryl M2 tablet can be used in the elderly only if it is recommended by your doctor. Do not use this medicine on your own.

When to take Isryl M2?

Isryl M2 tablet should be taken exactly as recommended by your doctor. It should be taken with meals, preferably with breakfast or the first main meal of the day.

Can I take alcohol with Isryl M2?

It is advisable not to consume alcohol during treatment with Isryl M2 tablet.

What are the symptoms of low blood sugar?

Some of the common symptoms of low blood sugar levels (also known as hypoglycemia) include sweating, tiredness, dizziness, shakiness, feeling of hunger, paleness and becoming easily irritated, tearful, anxious or moody.