Cizaspa-X Tablet

Mode of Action

How Does It Work?

Mebeverine and chlordiazepoxide are the active ingredients of Cizaspa-X Tablet. Mebeverine is a medication that reduces the motility of the gut by inhibiting a process called peristalsis. Peristalsis is the physiological process by which the food is transported through the various regions of the gut as digestion takes place. For this to occur, the smooth muscles of the gut contract and relax rhythmically. In IBS, this produces crampy, spasmodic pain. Mebeverine is an antispasmodic agent that causes relaxation of the smooth muscles, decreasing this forward propulsive peristalsis and reducing abdominal pain. It belongs to a group of agents called anticholinergics. Chlordiazepoxide is a benzodiazepine or tranquilliser that has calming, sedative effects on the brain. Studies have shown a direct correlation between increased stress levels, anxiety, & depression and IBS. Increased stress levels cause increased gut motility. Chlordiazepoxide acts as an antianxiety, stress-relieving medication. It does so by acting on certain brain pathways to increase the levels of a chemical called GABA (gamma-aminobutyric acid). GABA is a neurotransmitter, which means it is a chemical that relays information along brain pathways. GABA’s effects are predominantly inhibitory, hence increasing its levels produces the desirable effects in decreasing anxiety.